Furthermore, in murine breast and colon cancer models, Dewan et al. showed that 5 × 6 Gy and 3 × 8 Gy protocols of RT were more effective in inducing immune-mediated abscopal effects than a single ablative dose of 20 Gy when combined with anti-CTLA-4 hamster mAbs 9H10 [141]. This evidence concerns the gene CTLA4 and colonic neoplasm.