Due to the stress response that is induced by irradiation, the dying tumor cells experience a series of subtle changes involving the pre-apoptotic translocation of endoplasmic reticulum (ER) proteins, such as calreticulin (CRT) [82, 86], from the ER to the cell surface, and the release of damage-associated molecular pattern molecules (DAMPs) [87], such as high-mobility group box 1 (HMGB1) [88] and adenosine triphosphate (ATP) [89, 90] from the cytoplasm of stressed tumor cells to the outside environment. The gene discussed is HMGB1; the disease is neoplasm.