CYBB and epilepsy: Since neurodegeneration is mostly completed by 24h in this model, it is likely that NOX activation in microglial cells, but also neurons, orchestrate other mechanisms that lead to epileptogenesis, consistently with the multiple significantly changed downstream targets of Cyba and Cybb. The spatiotemporal pattern of the seizure-induced alterations in the NOX complex activity within the epilepsy focus is yet to be determined.