The main effects of the clustering of 4 MetS cardiometabolic risk factors were observed on insulin (Wald chi square = 15.1, P < 0.001, Fig 4A), chemerin (Wald chi square = 32.3, P < 0.001 Fig 4B), IL-8 (Wald chi square = 10.4, P = 0.001, Fig 4C), and visfatin (Wald chi square = 7.6, P = 0.006, Fig 4D). This evidence concerns the gene INS and metabolic syndrome.