Interaction effects between central obesity and the clustering of the other 4 MetS cardiometabolic risk factors were found for TNF-α (Wald chi square = 5.47, P = 0.019; Fig 2A), leptin (Wald chi square = 4.92, P = 0.027; Fig 2B) and adiponectin (Wald chi square = 9.17, P = 0.002; Fig 2C). The gene discussed is TNF; the disease is metabolic syndrome.