The main effects of central obesity were observed on insulin (Wald chi square = 17.4, P < 0.001, Fig 3A), chemerin (Wald chi square = 4.7, P = 0.031, Fig 3B), IL-6 (Wald chi square = 7.6, P = 0.001, Fig 3C), and PAI-1 (Wald chi square = 5.9, P = 0.016, Fig 3D). The gene discussed is INS; the disease is Abdominal obesity.