Numerous DNA viruses have been reported to activate the cGAS–STING pathway, and cGAS or STING deficient mice are more susceptible to lethal infection after exposure to many DNA viruses, including herpes simplex virus 1 (HSV-1), vaccinia virus, and murine gammaherpesvirus 68 (MHV68) [5]. The gene discussed is STING1; the disease is infection.