BRAF and neoplasm: CtDNA was detectable (average MAF = 7.4%, range 0.03–32.8; median mutant molecules/mL = 26.24, interquartile range of 8.42–1162.0) in 22 of 27 (81%) with BRAF mutations, in whom the average tumor burden was 379 mm (range 7–4278).