CYP21A2 and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency: Patócs et al reported that the prevalence of germline CYP21 mutations in patients with bilateral and unilateral adrenal incidentaloma were 21.1% and 16.1%, respectively[10]; however, accurate prevalence of adrenal incidentaloma with nonclassical 21-OHD still remains unclear.