Several studies have now reported prominent WMH in patients with familial FTD due to progranulin (GRN) mutations (Caroppo et al., 2014; Ameur et al., 2016; Kelley et al., 2009; Le Ber et al., 2008; Paternicò et al., 2016; Pietroboni et al., 2011; Sudre et al., 2017) but the pathological changes underlying these have not previously been studied in detail. This evidence concerns the gene GRN and frontotemporal dementia.