Inclusions of TDP-43 were present in neuronal cytoplasm and occasional neuronal nuclei, together with TDP-43 positive neuropil threads, particularly in frontal lobe grey and white matter, consistent with frontotemporal lobar degeneration with TDP (FTLD-TDP) type A pathology (Mackenzie et al., 2011). Here, TARDBP is linked to frontotemporal dementia.