GNRH1 and cancer: Although the ASCO Clinical Practice guidelines suggest that cotreatment with Gn-RH analogues may have some medical benefits such as the reduction of abnormal vaginal bleeding in patients with low platelet count consequent to chemotherapy, they state that there is insufficient evidence that Gn-RH analogues are a reliable method to preserve fertility, in view of the cost and potential relevant side effects such as bone loss, hot flushes, and possible interference with response to cancer treatment in estrogen-sensitive cancer [22].