In EAE mice, transplanted hESCs derived OPCs were shown to generate TREM2-positive CD45 cells, amplified TIMP-1 expression, restricted inflammatory cells to the subarachnoid space, and augmented the number of Foxp3-positive regulatory T-cells, potentially providing new avenues for stem cell-based treatment of MS [392]. The gene discussed is FOXP3; the disease is myeloid sarcoma.