192 IgG-saporin derived AD rats transplanted with embryonic rat NSCs induced by NGF-PEG-PLGA-nanoparticles facilitated differentiation of NSCs resulting in increased cholinergic neurons in basal forebrain regions, hippocampal synaptic formation, and generation of AChE-positive nerve fibers [22]. The gene discussed is NGF; the disease is Alzheimer disease.