KLK3 and Familial prostate cancer: We found that PSA nadir >0.5 ng/mL is significantly associated with not only biochemical failure (HR: 5.82, p < 0.001) but also distant metastases at 10 years (HR: 10.06, p < 0.001), prostate cancer-specific mortality (HR: 25.70, p < 0.001) and all-cause mortality (HR: 2.94, p < 0.001) at 10 years.