KLK3 and prostate adenocarcinoma: Several studies have previously looked at the relationship between PSA nadir and biochemical disease-free survival with varying PSA nadir cutoffs. Lee et al. studied 364 men with T1-T3 prostate adenocarcinoma who received definitive external beam radiation therapy >68 Gy and followed them for a minimum of 24 months with serial PSA measurements [9-10].