These transcriptome findings helped establish a molecular classification of two different HCC subtypes: 1) a proliferation class, with activated signaling pathways like TGF-β, MYC or PI3K-AKT, promoting worse clinical outcomes; and 2) a non-proliferation class, displaying activated WNT signaling in up to 25% of cases [17]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.