As expected from our previous findings, these combinations most strongly inhibited specific signaling mechanisms like MAPK-ERK (P-ERK-1/2) and AKT/mTOR (P-AKT473, P-GSK-3B and P-PRAS40 and P-S6), which are known to play an important role in the biology of HCC (Figure 4A and Supplementary Table 5). This evidence concerns the gene MAPK3 and hepatocellular carcinoma.