CD274 and neoplasm: All samples in our analysis had CD8+ lymphocytic infiltration within the tumor; however, In our homogenous series of primary LMS, lack of peri-tumoral CD8 infiltration, together with an absence of PD-L1 staining was in fact associated with the best clinical subset- alive and recurrence free in contrast to the patients in our series who had strong positive PD-L1 staining who had the poorest outcome.