SQSTM1 and papillary renal cell carcinoma: Moreover, the study of Qiu and colleagues [53] reported that tetrandrine (Tet:10μM), a natural product isolated from the root of Stephania tetranda, blocks autophagic flux in human prostate adenocarcinoma PC-3 and human renal adenocarcinoma 786-O cells, shown by the increase of LC3-II and SQSTM1/p62 when concomitantly treated with CQ (10μM) for 1h.