The Abcc6−/− mouse recapitulates features of PXE by developing late onset (5–6 weeks of age) and slowly progressing mineralization of the dermal sheath of vibrissae in the skin, Bruch's membrane in the eye, and in the arterial blood vessels of the cardiovascular system [18]. The gene discussed is ABCC6; the disease is pseudoxanthoma elasticum (inherited or acquired).