The majority of the patients were diagnosed with stage II colon cancers; more commonly having moderately differentiated adenocancers with diameters below 5 cm located in the right colon 89.19% of the patients had S100A4 expression in the tumor tissues revealed by immunohistochemical staining with a complete staining distribution of 52.03%. The gene discussed is S100A4; the disease is malignant colon neoplasm.