Moreover, in 2010, 296 breast adenocarcinomas and 38 ductal carcinoma in situ tissues were examined by Jubb et al. The study resulted in a Dll-4 expression associated with breast cancer cells, where Dll-4 was expressed by intratumoral cells in 73% to 100% of breast adenocarcinomas and 18% of in situ ductal carcinomas [83]. This evidence concerns the gene DLL4 and ductal breast carcinoma in situ.