AKT1 and leukemia: Furthermore, PAUF has been reported to be an endogenous ligand for TLR4 and can lead to activation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), protein kinase B (AKT)22, and p-38 of the innate immunity TLR signaling pathway without activating NF-kB in a human leukemia cell line (THP-1)25.