On the other hand, we first identified CRELD2 as a novel ER stress-inducible gene using microarray analysis of Tg-treated mouse neuroblastoma cell-line, Neuro2a3, and have been employing this Neuro2a cells to elucidate several ER stress gene expression (e.g., MANF, Chac1 and GADD153) in detail17,19,20. This evidence concerns the gene MANF and neuroblastoma.