SHMT2 and acute lymphoblastic leukemia: Key classifier-genes (Fig. 6C) matched prior qRT-PCR results (Fig. 3A, S2A), with both ALL types showing comparable levels of rag2, hMYC, and shmt2, a known direct MYC target (Fig. S8A) [21], reinforcing that hMYC levels and activity are similar in this dual pre-B/T-ALL model.