Separate comparisons of hMYC-1 or hMYC-2 vs. hlk ALL revealed that B cell-specific genes were up-regulated by both types of hMYC;GFP ALL (pax5, btk, cd81, etc.; Fig. 1B), with hMYC-2 ALL over-expressing additional B cell-specific genes (syk, blnk, ighm). Here, BTK is linked to acute lymphoblastic leukemia.