Similarly, ERK activation was evidenced to be involved in the upstream events of GLUT1 in the angiotensin II signalling scenario in diabetic nephropathy.34,37 The interplay between ERK and GLUT1 is reasonable and could occur at many levels due to the extensive functional or physical interactions between RAF/MAPK/ERK kinases with a wide range of scaffold proteins from other signalling cascades.48,49 Hence, mutual regulation between GLUT1 and ERK could affect various stages during OTM. This evidence concerns the gene SLC2A1 and diabetic kidney disease.