This extends prior knowledge of the associations of SH2B324 and B2M25 with hypertension as we demonstrate a unidirectional causal association between SH2B3 expression and plasma B2M levels, and thus provide plausible evidence for a causal role of the SH2B3-B2M axis in hypertension (Supplementary Fig. 2b). The gene discussed is SH2B3; the disease is hypertensive disorder.