They found that the conditioned medium from CAFs overexpresses specific factors, including IGF-1 and hepatocyte growth factor (HGF), which synergistically increase the expression and phosphorylation of annexin A2 (ANXA2), and are able to induce EMT phenotype and enhance NSCLC migratory potential (Figure 1). This evidence concerns the gene ANXA2 and non-small cell lung carcinoma.