Jiang et al. suggested that miR-7 plays a role in the modulation of IGF-1R expression in tongue squamous carcinoma cells [75], whereas McKinsey et al. proposed a novel complex mechanism in Ewing sarcoma (EWS) in which a set of miRs able to regulate negatively pro-oncogenic IGF-1R pathway components was repressed by the EWS-Fli1 oncogene [76]. The gene discussed is EWSR1; the disease is Ewing sarcoma.