However, human seipin, also known as the Berardinelli-Seip congenital lipodystrophy 2 gene (BSCL2), was found to not only be critical for adipocyte differentiation and lipogenesis induction using in vitro cell cultures [29], but is also linked to a more severe form of congenital general lipodystrophy characterised by insulin resistance, hepatic steatosis and extreme reduction in both metabolically active and mechanical adipose tissue in patient studies [30]. This evidence concerns the gene BSCL2 and generalized lipodystrophy.