Our data also showed that in both 2D culture and 3D mammosphere growth assays, activation of the iFGFR1 signaling increased the growth of DCIS-iFGFR1 cells, while KO of TNFAIP3 in these cells completely diminished the iFGFR1 signaling-induced cell growth. The gene discussed is TNFAIP3; the disease is ductal breast carcinoma in situ.