Interestingly, TNFAIP3 KO cells derived from the DCIS-iFGFR1 parent cells failed to respond to AP20187 treatment in terms of cell proliferation, indicating that TNFAIP3 is required for iFGFR1-mediated cell proliferation. The gene discussed is TNFAIP3; the disease is ductal breast carcinoma in situ.