The largest linkage scan to date for familial high-grade myopia utilized whole exome sequencing data from 254 families from five independent sites, demonstrating linkage replication of the high myopia loci MYP1, MYP3, MYP6, MYP11, MYP12, and MYP14, and identifying a novel locus at chromosome 9q34.11 [3, 4]. This evidence concerns the gene SCO2 and myopia.