MAPT and Alzheimer disease: After stratifying the dementia group by CSF AD biomarker profile, there was an association between CSF sTREM2 and CSF T-tau in both pathological subgroups (AD biomarker-negative: β = 0.004, P = 0.049; AD biomarker-positive: β = 0.005, P = 0.002) (Fig. 2d), adjusting for age, sex and disease duration.