In summary, we have demonstrated that high levels of the expression of HJURP are correlated with poor prognosis in HCC patients and promote HCC cell proliferation via the ubiquitination and cytoplasmic localization of p21 through the MAPK/ERK1/2 and AKT/GSK3β pathways (Fig. 8). This evidence concerns the gene GSK3B and hepatocellular carcinoma.