Based on these observations, the in vitro observation of increased CHI3L1 and LCN2 secretion in 4T1 + RAW264.7 co-cultures compared to 4T1 and RAW264.7 mono-cultures provided a preliminary indication of enhanced onco-immunological responses due to the crosstalk between the tumor cells and macrophages. This evidence concerns the gene LCN2 and neoplasm.