In our in vivo experiments, similar primary tumor levels but increased serum and spleen CHI3L1 and LCN2 levels were measured in 4T1 + RAW264.7 compared to 4T1 inoculated mice corresponding to the similar primary tumor growth in both inoculation groups, the increased metastasis and enhanced leukemoid reaction in the additional macrophages inoculation group. Here, CHI3L1 is linked to neoplasm.