Tumor-associated macrophages (TAM) are characterized as a M2 macrophage population producing key mediators such as matrix metalloproteinases (including MMP-9) and vascular endothelial growth factor (VEGF) that stimulate breakdown of the extracellular matrix (promoting tumor cell invasion) and angiogenesis (promoting tumor cell survival and metastasis), respectively [7, 8]. Here, MMP9 is linked to neoplasm.