Indeed, we previously showed that CHI3L1 and LCN2 levels increase progressively in primary tumors and sera of 4T1 intraductally inoculated mice and confirmed the increase in tumor-associated leukemoid responses as well as primary tumor growth and systemic metastasis detected by in vivo and ex vivo bioluminescence imaging [6]. Here, CHI3L1 is linked to neoplasm.