Some of these proteins are key components of cell-cell or cell-matrix adhesion (Additional file 1) and includes annexin and integrins such as ANXA1, ANAX2, ITGB1, ITGA3, FN1, CTNNB1, APOH which interplay may activate exosome and leukocyte adhesion to tumor cells to limit tumor growth. This evidence concerns the gene ITGB1 and neoplasm.