SHKBP1 and central nervous system cancer: In addition, the expression of circ-SHKBP1 is elevated in glioma-exposed endothelial cells (GECs), and promotes the viability, migration and tube formation of GECs via the miR-544a/FOXP1 or miR-379/FOXP2 pathway via the AGGF1 itself or though the PI3K/AKT and ERK 1/2 pathways [45].