Interestingly, the eclosion of the flies expressing Pcaf and htt simultaneously resulted in a non-significant higher degeneration than the sibling controls expressing the mutant htt. Additionally, the soluble Pcaf protein is altered in Httex1pQ93 flies and the mutant htt expression is not reduced; taken together, these results indicate that the reduction of Pcaf has a significant impact on HD pathology, however, therapeutic strategies to elevate the Pcaf levels are ineffective in ameliorating HD pathology [100,101]. This evidence concerns the gene KAT2B and Huntington disease.