All of these perspectives offer great possibilities for future lines of research in order to better understand and treat HD, and which would not be possible without the use of the Drosophila model and its extraordinary potential when using tools for gene expression, such as the GAL4/UAS system, UAS-RNAi, P-elements, genetics mosaics, and CRISPR. The gene discussed is LGALS4; the disease is Huntington disease.