At first glance, there is a stark absence of genome-wide significant effects for GWAS since only for the GWAS restricted to obese individuals is there a single strong association peak detected, which corresponds to the well-known obesity-driven signal at the FTO locus (top SNP rs11642015, p = 2 × 10−17). This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.