CASP3 and chronic myelogenous leukemia, BCR-ABL1 positive: In a chronic myeloid leukemia (CML) model using the K562 cell line, which is resistant to imatinib, it was found that an increase of phospho-p70S6K and a decrease of phospho-p53Ser15, Bax (Bcl-2-associated X protein), and active caspase-3 compared to the wild-type K562 cell line occurred [54].