MTOR and acute myeloid leukemia: Pradelli, et al. observed that the blockage of glycolysis, either through 2DG exposure or through glucose deprivation, induces AMPK-mediated inhibition of mTOR, with a subsequent reduction of myeloid cell leukemia-1 (Mcl-1) and a sensitization toward the action of death receptor ligands on Jurkat acute lymphoblastic leukemia (ALL) and U937 acute myeloid leukemia (AML) cell lines [23].