AKT1 and cancer: In the view of mTOR functioning as a point of convergence between a nutrient-sensing pathway (via-mTORC1) and as a regulator of Akt itself (via-mTORC2), the definition of the role of mTOR in controlling cellular metabolism and energy homoeostasis in normal and cancer cells plays a fundamental role in developing effective therapies for leukemia treatment (Figure 1).