Interestingly, Konopleva, et al. also reported that the Akt/mTOR pathway is strongly activated by co-culturing leukemia cells with mesenchymal stem cells in hypoxic conditions [32]; this observation is coherent with the idea that confers to mTOR the role of coordinating signals from microenvironment and subsequently adapting metabolism to these conditions. This evidence concerns the gene AKT1 and leukemia.