PTCH1 and adrenal cortex carcinoma: In a recent study, Hasanovic and co-workers [44] showed that methiothepin, a serotonin transporter antagonist [82,83], significantly enhances the cytotoxic, pro-apoptotic, anti-proliferative, and anti-clonogenic effects of doxorubicin on ACC cells by inhibiting the doxorubicin efflux activity of Ptch1.