The hypothesis that Ptch1 could be a multidrug transporter involved in chemotherapy resistance has been strongly strengthened by the observation, using Ptch1-silencing RNA, that doxorubicin efflux from the human cell line H295R, which was isolated from a patient diagnosed with an adrenocortical carcinoma (ACC), mainly occurs through Ptch1 and not through ABC transporters such as P-gp [44]. Here, PGP is linked to adrenal cortex carcinoma.