Likewise, some 10% of PD cases are strongly associated with α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) gene alterations [3,11,12], and approximately 3% of cases are associated with missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene [13]. The gene discussed is SNCA; the disease is Parkinson disease.