The senescence-accelerated mouse-prone 8 (SAMP8) mice demonstrate many features normally occur in the pathogenesis of AD such as abnormal APP processing by β and γ secretases and altered amyloid β (Aβ) proteins [18], elevated phosphorylation of tau [19], as well as synaptic and dendritic alterations [20]. The gene discussed is MAPT; the disease is Alzheimer disease.