The effect size of cagA negative H. pylori positivity was similar to that of Mexican Americans (OR 1.29; 95% CI 1.02–1.63), however, much lower than that of diabetes (OR 2.03; 95% CI 1.37–3.01) and hypertension (OR 1.67; 95% CI 1.26–2.19) (S1 Table). This evidence concerns the gene S100A8 and hypertensive disorder.