Li et al [3] found a stronger correlation between dyslipidemia associated genes (APOB, APOE-C1-C2, CETP, CYP7A1 GCKR, MLXIPL, PLTP, TIMD4) and glycemic traits including FG (fasting glucose) and HOMA-IR (homeostasis model assessment for IR, an important index for evaluating IR, calculated by FG* FI(fasting insulin)/22.5), which revealed the pleiotropic effects of dyslipidemia-associated genes on glycemic traits. The gene discussed is APOE; the disease is metabolic syndrome.