TGF‐β signaling plays a core regulatory role in the EMT process, and we previously demonstrated that APE1 promotes TGF‐β transcription in osteosarcoma, a malignancy derived from mesenchymal tissue.9 To further confirm this regulatory relationship in NSCLC epithelial cancer, TGF‐β secretion from cancer cells was evaluated by ELISA. This evidence concerns the gene APEX1 and cancer.