VEGFA and neoplasm: HCC is a typical hypervascular tumor, with high levels of VEGF receptor expression in tumor tissues.26, 27 Tumor angiogenesis plays an important role in the occurrence, development, and metastasis of HCC.28 It is also closely correlated with tumor stage and prognosis.29 A number of studies have been carried out to investigate the agents that targets VEGF axis for advanced HCC.