In summary, benefits of EGFR‐TKIs in EGFR‐mutated SCC patients are inferior to EGFR‐mutated ADC patients; however, unmatched EGFR‐mutated SCC and ADC patients may lead to bias, and the sample size of EGFR‐mutated SCC patients was very small. This evidence concerns the gene EGFR and AIDS dementia complex.