Some experts hold the view that some EGFR‐mutated SCC patients may also have a mixed ADC histology, and the sensitivity of EGFR‐TKIs in these patients might depend on the proportion of EGFR‐mutated ADC components in the whole tumor.40, 41 World Health Organization recommends immunohistochemistry not only for small biopsies/cytology, but also for resected specimens in certain settings such as solid ADC, nonkeratinization SCC, which guides the treatment.42 Furthermore, since the retrospective nature, the incidence of adverse events during the medication was lower than the actual situation. Here, EGFR is linked to neoplasm.