CDKN1A and Hutchinson-Gilford progeria syndrome: Moreover, accumulation of toxic levels of prelamin A or progerin, the mutated prelamin A form found in HGPS, was associated with upregulation of p53 target genes, including CDKN1A (Kudlow, Stanfel, Burtner, Johnston, & Kennedy, 2008; Varela et al., 2005).