POMC and Adrenal insufficiency: The area under the ROC curve (AUC) to predict adrenal insufficiency showed that the AUC for basal cortisol of < 8.7 μg/dL was 0.77 (95% CI 0.56–0.98), whereas those of ACTH ≥ 26.4 pg/mL and ACTH/cortisol ratio ≥ 3.3 were 0.63 (95% CI 0.39–0.88) and 0.75 (95% CI 0.55–0.96), respectively (Table 3).