TDP2 and Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to TUD deficiency: To address the relationship between mutations in the DNA strand break repair protein tyrosyl DNA phosphodiesterase 2 (TDP2) and spinocerebellar ataxia autosomal recessive 23 (SCAR23) and to characterize the cellular phenotype of primary fibroblasts from this disease.