Fautrel et al. (31) found that the expression of XPC in hepatic carcinoma tissue was significantly higher than that in normal hepatic tissue, and they speculate that the high XPC expression may lead to drug resistance of the liver tumor by enhancing DNA repair.The role of XPC in different tumors may be related to the mutation of the p53 gene. Here, TP53 is linked to hepatocellular carcinoma.