The phenolic 4-hydroxy group of 4, previously reported as essential for AR antagonistic activity,9 was either maintained, in order to evaluate its importance for anti-prostate cancer effect, or replaced with a 3-trifluoromethyl group, as a means to incorporate and evaluate one of the most successful modifications we have previously found in other series of related compounds.10,11. The gene discussed is AR; the disease is prostate cancer.