Animal studies of dendritic cell (DC)-derived exosomes showed improved tumor microenvironment by a significant increase in CD8+ T lymphocytes, elevated levels of IFN-γ and interleukin-2, and decrease in CD25+Foxp3+ regulatory T (Treg) cells and of interleukin-10 and TGF-β in tumor sites [84]. This evidence concerns the gene CD8A and neoplasm.