Among various factors, PDAC cells secrete Transforming growth factor beta-1 (TGF-β1), Fibroblast growth factor-2 (FGF2), sonic hedgehog (SHH) and platelet-derived growth factor (PDGF) that drive fibroblast proliferation and ECM deposition, which in turn, profoundly affect the cancer cell behavior [7-10]. The gene discussed is SHH; the disease is cancer.