TP53 and cancer: Typically, the top 10 KEGG pathways linked to all targets in the PPI network were obtained, including cell cycle (24), pathways in cancer (31), the p53 signaling pathway (15), the AGE-RAGE signaling pathway in diabetic complications (17), prostate cancer (16), endocrine resistance (16), hepatitis B (18), the PI3K-Akt signaling pathway (25), small cell lung cancer (14), and the FoxO signaling pathway (15) (Table 3).