T cell immunoglobulin and mucin-domain containing-3 is expressed on dysfunctional, tumor-specific CD8+ T cells in melanoma (60) and PCa patients (61), and in ipilimumab-treated melanoma patients, increased expression and frequency of TIM-3 and PD-1 on both peripheral NK and T cells associated with poor prognosis (62). The gene discussed is HAVCR2; the disease is melanoma.