Also in PCa, PD-1 blockade is clinically investigated in combination with ipilimumab (NCT02601014), anti-PD-L1 (NCT03170960, NCT03061539), and other therapies including hormone, vaccine, and cryosurgery (NCT02787005, NCT02499835, and NCT02489357). The gene discussed is CD274; the disease is posterior cortical atrophy.